De novo design of a novel oxazolidinone analogue as a potent and selective alpha1A adrenergic receptor antagonist with high oral bioavailability

J Med Chem. 2000 Jul 27;43(15):2775-8. doi: 10.1021/jm000085e.
No abstract available

MeSH terms

  • Administration, Oral
  • Adrenergic alpha-Antagonists / chemical synthesis*
  • Adrenergic alpha-Antagonists / metabolism
  • Adrenergic alpha-Antagonists / pharmacokinetics
  • Adrenergic alpha-Antagonists / pharmacology
  • Animals
  • Aorta / drug effects
  • Aorta / physiology
  • Binding, Competitive
  • Biological Availability
  • Blood Pressure / drug effects
  • Dogs
  • Humans
  • In Vitro Techniques
  • Male
  • Muscle Contraction / drug effects
  • Muscle, Smooth / drug effects
  • Muscle, Smooth / physiology
  • Oxazoles / chemical synthesis*
  • Oxazoles / metabolism
  • Oxazoles / pharmacokinetics
  • Oxazoles / pharmacology
  • Pressure
  • Prostate / drug effects
  • Prostate / physiology
  • Radioligand Assay
  • Rats
  • Receptors, Adrenergic, alpha-1 / drug effects*
  • Recombinant Proteins / chemical synthesis
  • Recombinant Proteins / metabolism
  • Recombinant Proteins / pharmacokinetics
  • Recombinant Proteins / pharmacology
  • Urethra / drug effects
  • Urethra / physiology

Substances

  • ADRA1A protein, human
  • Adrenergic alpha-Antagonists
  • Oxazoles
  • Receptors, Adrenergic, alpha-1
  • Recombinant Proteins
  • SNAP 7915